Simparica Trio vs NexGard Spectra – Detailed Comparison


For any pet parent, it is of utmost importance that their furry babies enjoy optimum health and remain protected from all kinds of parasites. When it comes to using broad-spectrum parasite protection for dogs, the two products that are widely chosen by dog parents are Simparica Trio and NexGard Spectra. Both these treatments are proven to be highly effective in external as well as internal parasites. However, the key question remains as to which one to choose between these two treatments.

In this blog, we have provided a detailed comparison of Simparica Trio and NexGard Spectra in order to help you decide the best suitable treatment for your animal companion. Read through to learn more:

Similarities between Nexgard Spectra and Simparica Trio

Both Nexgard Spectra and Simparica Trio are made in a palatable chew form.

Nexgard Spectra and Simparica Trio both protect dogs against fleas. In addition, either of these treatments is equally effective in preventing heartworm disease.

Differences between Simparica Trio and NexGard Spectra

Both Simparica Trio and NexGard Spectra are vet-recommended chewable treatments for dogs. They protect dogs from various parasites such as fleas, ticks, heartworms and intestinal worms. Let’s take a look at a few differences between Simparica Trio and NexGard Spectra:


Simparica Trio is manufactured by Zoetis Pet CareIt is a once-a-month chewable for dogs formulated with a trio of powerful ingredients and protect dogs against fleas, ticks, heartworms, roundworms and hookworms. It takes care of various tick species including Gulf Coast Ticks, Deer Ticks, American Dog ticks, Loner Star ticks and Brown Dog ticks. It also prevents Lyme disease in dogs.

NexGard Spectra on the other hand is an upgraded variant of the popular NexGard portfolio by Boehringer Ingelheim. The treatment protects dogs against fleas, ticks, mange, mites, heartworms, roundworms, hookworms and whipworms.

Composition and Efficacy

Simparica Trio contains Sarolaner, Moxidectin and Pyrantel, while NexGard Spectra is formulated using Afoxolaner and Milbemycin Oxime. Simparica Trio starts killing fleas within 4 hours of administration and NexGard Spectra starts killing fleas within 6-8 hours of administration.

Nexgard Spectra and Simparica Trio – Comparison Table

The table below features an extensive comparison between Simparica Trio and NexGard Spectra:


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Which one to choose, Simparica Trio or NexGard Spectra?

Both Simparica Trio and NexGard Spectra are equally trusted by dog parents because both treatments effectively protect against fleas, ticks (brown dog ticks) and heartworms.

However, if a dog is infested with mange and whipworms along with fleas and ticks then NexGard Spectra should be a good choice as Simparica Trio doesn’t offer protection against these pests.

Always take your vet’s opinion on which product to administer to your dog.

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